Bromelain is a mixture of enzymes found in the pineapple plant. Bromelain is often used as a dietary supplement for nasal swelling and inflammation, osteoarthritis, cancer, poor digestion, and muscle soreness. In spite of its use, the exact mechanism of action remains poorly understood. There is some evidence that bromelain may be useful as adjunctive therapy to help improve acute nasal and sinus inflammation
- A 2014 prospective, placebo-controlled trial of 34 patients evaluated the anti-inflammatory and analgesic effect of bromelain in the postoperative after extraction of impacted lower molars. The study found no statistically significant differences between the bromelain and placebo groups, a trend toward less inflammation and improved oral aperture was observed in the bromelain group, compared to placebo.
- Findings from a 2006 systematic review of three randomized controlled trials suggest that bromelain is helpful in relieving symptoms of acute nasal and sinus inflammation when used as adjunctive therapy with standard medications such as antihistamines, analgesics, and/or antibiotics.
- A 2004 review concluded that current data suggests the potential of bromelain in treating osteoarthritis, but that further studies are needed before a definitive conclusion can be drawn.
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